Based on this detailed layman’s study of Andro400, it appears far less efficient as a weight loss supplement than as a testosterone booster, unless you consider its claim of increased energy as an incentive to get you moving—although Andro400.com claims you will lose belly fat with its product (we’ll see about that shortly).
Andro400’s main ingredient is a Southeast Asian herb, Eurycoma longifolia (Tongkat Ali), which closely mimics the effects of the steroid androstenedione, used primarily (but not exclusively) by men to elevate testosterone levels for performance enhancement in the gym, on the field, or in the bedroom, apparently. The latter is probably the most likely result of taking this herb. 
Andro400 is manufactured by Natural Health Concepts, located in West Palm Beach, Florida. It came on the market in 2004. Contact by phone is 877-711-3173, by email [email protected] . The company is not listed on the Better Business Bureau website, though.
Andro400 promises to deliver “energy, strength, stamina, improved muscle tone and mass, enhanced libido and sexual performance, enhanced immune system, mental clarity, as well as reduced body fat, especially in the abdominal area.” It says it “melts belly fat.” 
Andro400 claims users will experience no side effects and is completely safe to use (we’ll get to the question of safety in a minute.) Let’s qualify that statement: Andro400 claims no “harmful” side effects in its statement on the website in answer to a FAQ:
No, because the ingredients are 100% natural. There are no chemicals, drugs, synthetics, hormones, steroids or even caffeine in Andro400 or Andro400 Max, so there are no harmful side effects whatsoever. 
Andro400 describes itself as “the leader among natural testosterone boosters with a proven track record of successfully helping tens of thousands of customers increase their testosterone safely without side effects.” 
Andro400 says “no strict diet or exercise regimen is required to lose fat with Andro400, you may need to alter your diet depending upon your current eating habits” especially sugar and processed foods with high fructose corn syrup, which Andro400 says “actually blocks testosterone production up to 25% and can keep Andro400 from working as effectively as it could work to help you lose fat.” 
There it is: with this supplement, you need to diet to lose weight. So in theory, you could ditch the supplement and just diet to lose weight, period. Andro400 also says “getting some form of exercise” will help you to lose weight. They’re not lying about that.
Eurycoma longifolia (root) Extract 600 mg, Microcrystalline Cellulose, Rice Flour, Silicon Dioxide, Magnesium Stearate & Vegetarian Capsule. It also apparently contains L-Arginine and L-Citrulline, but they’re not listed on the label. 
The Science (or Lack Thereof) Behind Andro400
First—and this should appear in all discussion of weight loss supplements, since they are considered dietary and not drugs—the FDA does not regulate them. That said, supplement labels are prohibited from claiming any medical or health benefit because of course that would be a medicine or drug, the FDA’s purview. The whole issue is dicey and there’s no shortage of FDA and Federal Trade Commission cases brought against supplement manufacturers. Every claim Andro400 makes includes an asterisk to remind folks about its disclaimer
As with other dietary supplements, it is subject to inspection by the FDA for compliance with Current Good Manufacturing Practice (CGMP) regulations in Manufacturing, Packaging, Labeling, or Holding Operations for Dietary Supplements. 
Safety? Even if, as alleged, E. longifolia does increase testosterone, the FDA stated in a 2002 notification about the labeling of supplements containing E. longifolia, “it could pose a safety risk in men with prostate cancer or other medical conditions. “ 
So what does science say about E. longifolia? The southeast Asian tree has been used in traditional herbal medicine practiced in Malaysia, Vietnam, Laos and Indonesia, among other countries, to treat a number of gastrointestinal ailments, to be used as a tonic for increased energy and stamina, and—its primary use—as an aphrodisiac or to improve male sexual performance and health.
The greatest issue with E. longifolia found in dietary supplements is contamination and/or adulteration—dubious ingredients purported to be E. longifolia. The FDA cracked down on this in 2009. A thorough search by this reviewer to see if Andro400 was among the supplements with suspect ingredients found they were not, so it appears the E. longifolia in Andro400 is the real deal.
The good news for users is that study after study from the National Institutes of Health (NIH) show it likely does increase libido and its claim as an aphrodisiac that benefits men’s sexual health. And it may—emphasis on may—increase testosterone, though further study is required, NIH says.  
But as far as weight loss? Here’s where it gets tricky. Low testosterone may affect increased abdominal fat in men. So in theory, more testosterone would help to, as Andro400 claims, “melt belly fat.” And increase metabolism and muscle mass.
The problem is the lack of definitive evidence that establishes E. longifolia actually does increase testosterone, as evidenced by this NIH study that found “At the end of the 6 weeks of treatment …the testosterone level of the (E. longifolia) group was not significantly different” from the group without being treated with E. longifolia.
However, some studies say it may block the sex-hormone-binding globulin (SHBG) in your blood, which tend to bind testosterone molecules. If that is true, then perhaps the now free-roaming testosterone particles will increase. Anecdotally E. longifolia does appears to handle the bedroom part pretty well, so it’s a toss-up.  
Also…it’s impossible to target fat. The body burns fat wherever it happens to find it first. Usually that means from the top down. If all you have is abdominal fat, then yes, that will burn first. But it’s not a given. Eventually the body will get around to all of it, but you can’t target it. 
Building muscle can be targeted, by specific weight training exercises. As you build muscle, your body automatically burns more energy to feed that new muscle. If you’re not sucking up huge amounts of carbohydrates, then the body will turn to burning stored fat. So in a nutshell, target muscle build = random fat burn. 
Word on the Street About Andro400
Reviews are mixed.
On its website, not surprisingly, scores and scores of reviews are enthusiastic. A good example is “Michael David” of Seattle who says,
I’m 51 years old. In just 6 months of using Andro400 I have lost 35 lbs. and went from a size 38 to a size 32 waistline. I have more energy and look and feel 20 years younger! My wife even says that I have to use your product. Thank you Andro400 for my brand new healthy lifestyle! 
Andro400 is not sold on Amazon, but it is all over eBay from myriad sellers. User and reviewer “Bill Crum” said he took the supplement, while adding a new diet and exercise regimen, and lost weight. But, after seeing his doctor to check out his testosterone levels he was told “…it was still low, so I'm not sure if this product has any effect on T levels.” 
“Bill” was not alone. But there were a number of positive reviews.
There’s eBay user “patriot4ever818,” who had nothing but the highest praise.
I haven't had the time to train for the past couple years and my test levels have dropped significantly. I started Andro 400 just one pill a day and my Testosterone levels are back up and I've lost 15 pounds. Muscles feel full and I’m ready to start training again. Great product. 
Finally, “Mike5Star” says save your money.
I have completed my 3rd month using Andro400 and I have not lost any weight, but I have gain weight! No noticeable change in my figure, still have a gut. I have been eating right, better than I ever have. I have read that people stopped taking it after 2 months because they were not seeing any change, but after their 3rd month there was a change. Just a ploy for you to just buy another month of the product. Join a gym, ride a bike, swim, just get out and exercise. This is not the miracle drug that they state. Waste of money! 
Is Andro400 worth a try?
Insufficient Data to Praise or Pan. As a supplement for male sexual performance and enhancement, it’s probably a go. Beyond that, it’s a no-go. There’s just little evidence it does much, though don't tell that to the hundreds of reviewers who stand up for Andro400 and love this product. Then again, there are likely nearly as many who were not satisfied or found it a dud—which could be said for any product. But when we’re talking about male sex drive and performance, the mixed results and reviews are a bone of contention.
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