Leptigen says it was looking for a “better way” to help people lose weight when its researchers created a weight loss formula it claims is powerful, effective, safe, and sensible. The “scientifically formulated” supplement accelerates fat burning and loss, decreases the likelihood of “weight-loss plateaus,” kickstarts metabolism and “controls blood-sugar levels for optimum weight control.” 
Leptigen is manufactured and distributed by Green Bracket, LLC, headquartered in Coral Gables, Florida. Green Bracket also runs the diet review website DietSpotlight.com (where it always “suggests” Leptigen as an alternative to other diet pills it’s not so keen on). It has a Better Business Bureau (BBB) profile, but no rating—which is rather strange, given the 15 customer reviews are 80% negative and there are 102 registered complaints since the profile was opened in 2008 (same year the company started). The BBB gives this as their reasoning: “BBB is evaluating a pattern of complaints before issuing a rating.” 
Given that the vast majority of the complaints have to do with a scam called “negative option marketing,” I suspect that rating will drop like a proverbial rock once the BBB finishes their evaluation. 
You’ll lose weight, Leptigen says, in large measure because of an ingredient called Meratrim, which appears to be the elixir; it’s noted as the “key ingredient.” We’ll get to that.
Describing itself as a trusted name in weight loss for nearly a decade, Leptigen promises you’ll be satisfied with the results and offers a 120-day money-back guarantee to back that up. At nearly $110 per bottle—a one-month supply—results are expected. The claim is that with a cranking metabolism, curbed appetite and boundless energy, you’ll probably exercise, or at least move your body more. With mild side effects that are primarily GI-related, the product is “safe and reliable.” 
Leptigen boasts it’s the only weight loss supplement that “effectively combines Meratrim, ChromeMate, green tea extract and caffeine.” The first two are proprietary formulas that do most of the heavy lifting (no pun intended), and in the case of Meratrim there’s some actual science behind it. 
Before we get to a closer look at what’s inside Leptigen, a quick note about Leptigen Rebirth, which many people search for online.
Here’s the thing: it either doesn’t exist or, if it did, it was made by Avant Labs—though the site does not include the product and Amazon and a slew of other sites I scoured do not have it. The only place I saw it described has no link to purchase it. I think it’s bogus. But let me know if you learn otherwise.
Leptigen, on the other hand, is real and has been around since 2008. But one thing I did find while hunting the elusive Rebirth is that the basic Leptigen seems to only be good if you’re less than 20 percent body fat. I didn’t find specific articles—and of course the company really has no incentive to mention that to prospective customers—just a lot of chatter about that on bodybuilding forums. So it may well be useless for anyone needing to lose a lot of weight. 
Meratrim consists of two plant-based compounds: Sphaeranthus indicus (East Indian Globe Thistle) and Garcinia mangostana. S. indicus is a flower extract that has been used for reducing stress, fighting free radical damage and reducing inflammation. When used in combination with G. mangostana it is clinically shown to improve weight loss. 
- G. mangostana is also known as mangosteen. The fruit extract has been historically used for mental illness, diarrhea, thrush, tuberculosis and urinary tract infections. In Meratrim, when mangosteen is combined with indicus it can promote weight loss.
ChromeMate, the other featured ingredient is said to help support blood glucose and cholesterol levels. The science on this is sketchy. 
The other two ingredients are green tea extract and caffeine. There’s few weight-loss supplements out there that don’t feature both. The good news is Leptigen isn’t loaded with caffeine (each pill contains about the equivalent of half a cup of coffee, according to the label), which could be an issue for some people.
The Science (or Lack Thereof) Behind Leptigen
Leptigen says there’s a lot of research on chromium. That’s true.
Chromium picolinate may help regulate blood sugar, and those glucose levels are directly related to hunger and cravings, especially for sugary foods—though we’re not always talking sweets; just good old-fashioned white stuff like pasta, bread, rice and potatoes) 
You know the feeling: you’ve eaten a big meal loaded with carbs and soon thereafter, you’re hungry again or craving that sugar because once your body has processed the carbohydrates, the blood glucose that had spiked, falls. The idea with chromium is that drop is not so precipitous.
But—there’s always a “but”—this is ChromeMate. I don’t need to go through all the claims; just suffice it to say the US Food and Drug Administration (FDA) rejected most as either having no credible scientific evidence for effectiveness at all or, as in the claim of help with insulin resistance, there is “very limited credible” evidence. 
A study Leptigen points to as being proof of ChromeMate’s effectiveness is the 1996 “Chromium and Exercise Training: Effect on Obese Women,” conducted by the Exercise Physiology and Metabolism Laboratory in Department of Kinesiology and Health Education at the University of Texas-Austin. The study, published in the August 1997 Medicine and Science in Sports and Exercise journal, does show that there was weight loss in the clinical trial, referred to as “significant”—it amounted to one pound. Technically that’s weight loss, I have to agree. But not much.
Another but: it turns out—and this is buried deep in the study—researchers say clearly:
Our results indicate that without exercise, not only may chromium picolinate supplementation be ineffective in causing weight loss, but may result in weight gain. 
Now this might be described as significant: if you take this supplement and do not exercise, you may actually gain weight.
In summary, high levels of chromium picolinate supplementation without concurrent exercise training caused significant weight gain in young, obese females, while exercise training combined with chromium nicotinate supplementation resulted in several potentially beneficial changes, including significant weight loss and a lower insulin response to an oral glucose load. 
Oh, and the study was funded by supplement manufacturer Shaklee. Draw from that any conclusion you wish. So that’s that on ChromeMate.
Meratrim, on the other hand, may work. In a widely published and cited study, subjects in a clinical trial saw significant reduction in weight compared to subjects given a placebo. They also ended up with smaller waist and hip measurements. And they kept the weight off.
Two studies in the vast archives of the National Library of Medicine agree that “study findings suggest that Meratrim is well-tolerated and is an effective ingredient for weight management in healthy overweight subjects.”  
So maybe you just take that supplement?
But wait, the first of those two studies, which found
…supplementation of the herbal blend at a daily dose of 800 mg resulted in statistically significant reductions in body weight, BMI, and waist circumference that exceeded those achieved via diet management and moderate exercise alone. Its significant effect on body weight reduction was seen as early as 2 weeks…also resulted in statistically significant reductions in serum cholesterol and triglyceride concentrations. Analysis…[indicates] that the herbal blend is well-tolerated with minimal side effects. Thus, these observations indicate that this herbal blend is promising as a weight loss ingredient; however, longer term studies are needed as the current study was relatively short-term with a small sample size. … In conclusion, the blend of S. indicus and G. mangostana we tested demonstrated weight loss efficacy over a short duration of 8 weeks and was well tolerated. 
was paid for by the makers of Meratrim—InterHealth USA—with an “unrestricted grant.” Which I take to mean at whatever cost by researchers at University of California Davis and scientists at a hospital in India. 
Does that matter? Could there be bias? You decide.
Word on the Street About Leptigen
Of 52 reviews on Amazon, well over half were critical—very critical. The overall rating is 2.3 out of 5 stars. 
Reviewer “Viktor Kerr” (2017, 1 star) said his doctor cautioned him against using it—though did not explain why, other than to allege it’s “dangerous” and advised people to check with their doctors before using it. That’s good advice on any supplement, frankly. 
The majority of other very negative reviews complained Leptigen either “did nothing” or made them feel ill. Like “James R. Breckenridge” (2017, 1 star) who says the product, “Kept me up all night with my heart pounding. I almost went to the ER. They need to make people more aware of this.” 
And “Robert Brady” (2017, 1 star) warns it’s pouring money down the drain: “This did nothing for me. I stuck to it meticulously for 30 days. Do NOT waste your money on it.” 
But there were folks who sang the praises of Leptigen. Actually, of 52 reviews, precisely three reviewers gave Leptigen a five-star rating; two are named just as Amazon buyers and I generally don’t quote reviews without some kind of name, moniker or even an avatar. Suffice both said it was great stuff and little else. The third five-star reviewer, “Rzr,” had quite a lot of trouble spelling but it appears that s/he lost five pounds in a week. I think. 
More realistic and sensible was a candid review from “JenRog,” (2016, 3 stars) whose review was considered helpful by dozens of people looking at the product.
This product is okay and with diet and exercise does curb your appetite, but if overeating is not your problem with weight than this is probably not the product for you. I didn’t feel any jitters or anything like that. I didn’t really notice any difference taking it. My friend took it at the same time and she said it curbed her appetite and she lost a couple pounds, but overeating is a problem she has…so it could work for you if that is a problem you have. 
The Bottom Line: Is Leptigen Worth a Try?
Depends. Leptigen sounds great actually. It may help diabetics control their sugar. You might lose a few more pounds while dieting and exercising with it than without it. There are few side effects, save for the occasional tummy trouble and—for the caffeine-sensitive—some jitters or insomnia. And there is talk around the bodybuilding forums that it really isn’t for folks over 20 percent body fat.
Yet with all that said, I’m not a fan because it’s just too expensive. That’s my bottom line. Nearly $120 for one month’s supply of one supplement is nuts. And that’s without the whole negative-option marketing thing through the company. If you have the money though, it might be worth a shot. Just know what you’re getting into. Keep me posted.
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