What is Plexus Slim? Sometimes called the “Pink Drink,” Plexus Slim helps to improve gut health and support healthy glucose metabolism. To lose weight, you mix a single-serve packet into a bottle of water and drink it before meals; to just generally support a healthy digestive system, drink it whenever, just not more than twice a day. 
Plexus Slim is only available for purchase on the company website, with a few offerings on eBay. One 30-serving pack costs a whopping $87.95 plus shipping. If you’re taking it to lose weight, that means one pack lasts just ten days. 
Plexus Slim is made and marketed by Plexus Worldwide, LLC, headquartered in Scottsdale, Arizona. They have an A-plus rating with the Better Business Bureau, but also have a customer review rating skewing to the negative—31 to 67 percent—and over 650 customer complaints in 9 years of business (3 years incorporated). However, that A-plus rating with that many complaints generally means they’ve been very good about taking care of their customers. 
NOTE: There is a notice about FDA action on Plexus Worldwide’s BBB profile; it is not in relation to Plexus Slim, but to three other products.
Plexus Slim Claims 
- Clinically demonstrated to help you lose weight*
- Promotes the growth of good gut microbes◊*
- Increases Lactobacillus by 365 times and Bifidobacterium by 290 times- contributing to overall health◊*
- Increases the metabolism enhancing Akkermansia microbes by 250 times◊*
- Supports healthy glucose metabolism*
To be fair, Plexus Slim posts, albeit in very small letters, that its claims are based on studies with a “human gut simulator” which suggest that “Slim’s formula may have several beneficial effects.”
“Further research, including research conducted in humans, is needed to confirm these preliminary findings.” 
Plexus Slim Ingredients
It took way too much searching to track down a picture of the Supplement Facts on the back of the Plexus Slim bag—it’s not available on the company website, and most of the eBay offerings didn’t bother. But one did. So we have an ingredient list:
Chromium (as chromium polynicotinate), 200 mcg
Xylooligosaccharide, 1000 mg
Plexus Slim Blend, 531 mg: Green coffee (Coffea robusta) bean extract (contains 50% chlorogenic acid and less than 2% natural caffeine), Garcinia cambogia fruit extract, alpha lipoic acid, Mulberry (Morus alba) fruit extract.
Other Ingredients: Citric acid, natural flavors, stevia (Stevia rebaundiana) leaf extract, beet (Beta vulgaris) root extract and other fruit and vegetable juice (for color), cellulose gum, silicon dioxide.
Not recommended for use by children under 18. If pregnant or nursing, consult your physician prior to use. Keep out of reach of children. 
There’s a very long word in that list: Xylooligosaccharide (zy-loh-oh-lig-oh-sack-a-ride). It’s actually a prebiotic that acts as a sort of fertilizer for growing good gut bacteria. Yes, things are growing in your tummy and digestive system, and in order to lose weight it’s best that those microbes are good gut flora.
You’ve heard of probiotics, mostly from yogurt commercials. Probiotics do deliver good bacteria to your gut (bowel, colon, etc.), but prebiotics are dietary fibers that act as a fertilizer to grow that good bacteria.
Prebiotics come from plant fibers and can be found in foods like Jerusalem artichoke, avocado, jicama and chicory root, and allium (Latin for garlic) plants—garlic, leeks, onions, shallots, chives, and the like—as well as breads made from 100 percent whole or sprouted grains. None of these are actually digested by the body; instead they just promote the growth of the good gut stuff that works against fat. If you love to cook with onions and garlic, there’s little doubt that the best way to get prebiotics in your body is through foods like these. Short of that, a blend with myriad prebiotics is the other way to go.
Also included is essential nutrient chromium, which helps metabolize fats and carbohydrates; alpha lipoic acid, which is a natural antioxidant; and the popular weight-loss supplement Garcinia cambogia (hydroxycitric acid), which is known to help assist in losing body fat—and some studies claim it may suppress appetite, but the jury is still out on that. Plexus Slim also contains green coffee extract (chlorogenic acid), which stabilizes blood sugar levels, and so-called “superfood” mulberry.
Raspberry, lemon and watermelon-flavored, people either love or hate the taste. The ‘Pink Drink’ must be mixed with at least 12 ounces of water (preferably more) about 30 minutes before meals.
The Science (or Lack Thereof) Behind Plexus Slim
Let’s go back to xylooligosaccharides (XOS) for a moment, a “fiber that friendly microbes love to eat,” and a fiber that the National Institutes of Health (NIH) says, “provide a plethora of health benefits.” Plexus Slim claims its “premium microbiome activating formula” is “clinically demonstrated to help you lose weight” by promoting good gut microbes. And claims that XOS have been “clinically shown to improve intestinal microflora for enhanced health and well-being.” 
Note: In order to stay out of trouble with the FDA, Plexus cannot say “clinically proven”—it doesn’t mean the science isn’t there, just that there hasn’t been enough clearly consistent peer-reviewed evidence for the FDA to reclassify XOS as a drug rather than a supplement. Thus the alternate wording and the standard disclaimer on the package.
According to the Mayo Clinic, while you may not necessarily need more of the good bacteria in probiotics, microorganisms that help your gut by protecting against harmful bacteria, unless you’re already consuming foods like yogurt, whole grains, artichokes, garlic and bananas, for example—a dietary supplement packed with probiotics might be the way to go. 
Additional research is needed, the Mayo Clinic says, but there’s “encouraging evidence” that probiotics may help treat diarrhea, prevent and treat yeast infections and urinary tract infections, treat irritable bowel syndrome, speed treatment of certain intestinal infections and prevent or reduce the severity of colds and flu. 
And while side effects are uncommon—and healthy adults generally can add prebiotics and probiotics to their diets—check in with your doctor first, just in case. 
Plexus Slim side effects include temporary bloating and or gas—which Plexus Slim says can be avoided by beginning with a half dose and then gradually increase over one to two weeks. The only other adverse side effect I’ve found is from users who have reported allergic reactions.
Word on the Street About Plexus Slim
Plexus Slim reviews are not easy to find, at least what appear to be objective reviews, not paid or promoted endorsements. Weight loss products and supplements can often be found on Amazon.com. Plexus Slim is not one of them, but it can be found on eBay. Reviewers there—the small number of them—had little to say about the product specifically, save a very recent review by a customer who said,
It works but you have to give it at least 60 days. It’s best combined with bio cleanse and pro5. If your gut is not healthy then it effects your entire body. Get your gut healthy. 
On the Plexus Slim site, with 172 reviews, it earned a 4.7 average. Not surprising, really, given that company websites can have a tendency to skew which reviews they show toward the positive. But, that said, there were a number of poor reviews and even a number of very poor reviews as well, including a recent one by user “Debbie” who said,
Something in the new slim has put my bladder on overdrive. I stopped taking it and it went back to normal. So must be having a reaction to it. 
User “Melissa” also had a bad reaction:
The new Slim is awful, I have extreme itching and neck stiffness just days after starting it and pretty sure I’m allergic to something in it. 
The Bottom Line: Is Plexus Slim Worth a Try?
Depends.A healthy gut is an overall win for your body, so incorporating prebiotics into your diet is just smart, whether it’s from plant-based foods or a product like Plexus Slim.
Here’s the thing about Plexus Slim: If while on a diet and exercise regime you add Plexus Slim and lose a pound or two more than without it, it’s maybe not a poor purchase. Unless cost is an issue for you, because Plexus Slim’s cost may be a deal-breaker at nearly $90 for just ten days of weight-loss servings.
Top 5 Diets Compared*
6 Month MBG
|Trim Down Club||$||–|
|Mayo Clinic Diet||$$$||–||–||–|
*Individual results will vary.
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