By CANDICE GREY
Update: May 23, 2022
Acxion (Acxion Fentermina 15mg/30mg) is a brand-name phentermine drug available only in Mexico. Phentermine is banned in the UK, and a controlled substance in the United States, available only with a prescription.
But Medicines Mexico RX online pharmacy doesn’t require a prescription for you to purchase Acxion or any of their other products. Their rationale:
You keep your medical needs private from your employer, health insurance company, and even your bank with our international pharmacy and secure, anonymous credit card processing. No prescription to purchase any medicine in our pharmacy. We are a licensed pharmacy in Mexico and available to answer your questions. 
Now, before you make a beeline for the website, please take the time to read the rest of the review where I dig a little further into phentermine and why it’s classified as a controlled substance in the United States.
Acxion pills are tiny and easy to take with you wherever you go, and the only active ingredient is phentermine hydrochloride. It is produced by Investigacion Farmaceutica, in Morelos and sold worldwide on the Medicines Mexico RX website. It appears you can get it over-the-counter in Mexico; I found a thread on MedsChat.com where people had said they purchased it there without a prescription. 
Company Contact Information: Medications México S de RL de CV Golfo de Akaba 7B (oriented) Acapulco, Guerrero 39350 México. USA Toll-free 1-866-439-4963; Support@MedicinesMexico.com. Calle Calle 13 Este 5, Col. Zona Indl Civac Jiutepec 
Because Acxion is marketed on Medicines Mexico RX as a non-prescription, they can charge a little more because they know there are people who will buy it. A 30-tablet package of 15mg pills costs $60.50 plus shipping—nearly three times what a US prescription can run with pharmacy coupons or discounts. The same amount of 30mg tablets cost $104.50, plus shipping. So trying to work around your health care provider is going to cost you, probably in more ways than just your wallet.
And Medicines Mexico RX doesn’t do returns. At all. They cite government regulations:
Due to government regulations and the possibility of tampering with medications, returns cannot be accepted. Due to our policy of same-day payment processing, ORDERS CAN NOT BE CANCELLED.” 
So no returns and no cancellations. Hmm.
The sales page for Acxion on Medicines Mexico RX is very straightforward. It explains how phentermine works, the dosage, the side effects, precautions about being completely honest with your doctor about what you’re taking (which is kind of funny, since the whole reason they’re selling this stuff is to sidestep prescriptions), information about drug interactions and abuse potential, and the treatment if an overdose occurs. There are no flashy pictures, no buzzwords in bold print, and no exclamation points.
There isn’t a photo on the whole Net of the back label. But www.Catalog.MD does list Acxion’s ingredients: The only active ingredient is Phentermine Hydrochloride, 15 or 30 mg depending on which version you get. 
The Science (Or Lack Thereof) Behind Acxion
Phentermine is a potent appetite suppressant; it’s also an amphetamine. It was created specifically to help individuals with serious weight lose—over 100 pounds, having a BMI of 30 or higher—for which other methods have not worked, or in order to be stable enough for surgery (like the stomach-band surgery for further weight loss).
Phentermine is supposed to be used under strict doctor supervision only for brief stretches of time (six weeks or less), as there are many side effects—some very serious—that can occur when taking it. And it has a risk of addiction.
The US Food and Drug Administration (FDA) and the US Drug Enforcement Agency (DEA) have classified Phentermine as a Schedule 4 (IV) controlled substance/drug. “The drug has a low potential for abuse relative to the drugs in schedule 3 The drug has a currently accepted medical use in treatment in the United States. Abuse of the drug may lead to limited physical dependence or psychological dependence relative to the drugs in schedule 3.” 
According to Catalog.MD,
Phentermine acts on the brain’s neurotransmitters. This medication is a central stimulant and an isomer of methamphetamine. It stimulates neurons to release a particular group of neurotransmitters known as catecholamines among which are dopamine, epinephrine (also called adrenaline), and norepinephrine. The appetite suppression activity of these compounds is due to their action on the central nervous system. 
Other studies have been done on the effect of Phentermine on the body, and how it correlates to weight reduction and overall effectiveness in the body. In a study done on overweight Korean people published in the 2006 Yonsei Medical Journal, 80 men and women over the age of 20, categorized as obese via their BMI, took phentermine over the course of two week time period. Some participants were eliminated for not following the rules.
There were no significant differences in systolic and diastolic blood pressure between the groups… Dry mouth and insomnia were the only statistically significant adverse events that occurred more frequently in the phentermine group. Most side effects of phentermine were mild to moderate in intensity. Short-term phentermine administration induced considerable weight reduction and reduction of waist circumference without clinically problematic adverse events in relatively healthy Korean obese people.  (emphasis added)
Word On The Street About Acxion
Because Acxion can only be purchased in Mexico, reviews are more available on message boards than on sales pages. So I also pulled a few reviews on phentermine in general as well.
Let’s start with the specific Acxion reviews.
“If you take Acxion you WILL show positive for amphetamines. They can also cause irregular heartbeat, nausea, and high blood sugar, which is part of why it is not allowed in the U.S.!”“Plenty” (2016) mentions something interesting: “I definitely feel like they are not as strong as phentermine.” “kaspergirl” (2016) agreed, saying “I have had this same thing happen to me….at times I can feel them, and other times it feels like I could take 10 pills”
One concern with websites that offer prescription medicines with no prescriptions is it does leave a window open for scammers selling a “brand” and then actually providing a knockoff with unknown ingredients. A no-cancel, no-return policy like the one on Medicines Mexico RX does make you wonder.
On the Consumer Affairs website regarding phentermine, a clearer picture of the potential side effects.
“Sarah” (2017, 1 of 5 stars):
I absolutely loved Phentermine. The first week I took it in half doses. The 37.5 tab broke in half — one half in the morning, one half at lunchtime. I had the energy to the moon. I cleaned like I was going to have a health inspection. I lost weight for 5 months. I also lost my own sanity… my mindfulness. I was so easy to anger, and could not be pleased; everyone made me angry, nagging, hurtful, rude, and nights of no sleep or sleep maybe a few hours.
I lost over 50 pounds on the scale but looking at it with clear eyes, I lost water weight and muscle. My body was starving. I was not told how to take it or how to take care of myself on it. Hair loss, bad skin, dry mouth, and chapped lips. The list could go on forever. I took myself off this medication. I did not see results, and the doctor thought I should continue even though I had already been on it too long without even a break. I gained all my weight back as I got my first period since starting the medication. I do not recommend this at all. My life has changed and not for the better.
“Ashley” (2016, 3 stars) said,
I first started phentermine back in 2009 & I lost a total of 80 pounds in 5 months with diet & exercise, but I started to have bothersome side effects like lack of sleep, sleep paralysis, and agitation. I also suffer from bipolar disorder. I have been on phentermine again for two months & have lost a total of 60 pounds, which is helping wonderful with my weight. But the side effects I’m having now are Hallucinations, visual & auditory.
“Teresa” (2017, 1 star) had a bad scare:
I have been taking Phentermine for a couple of years now. I have actually gained weight on this pill… Up to 7 pounds in less than 1 month. I used to weigh around 120-125 before my hysterectomy. Afterward I jumped up to 140-145, and I am now around 158-160… Still taking pills and no significant losses. I did lose 5 lbs in 1 month. I just can’t seem to get the weight off. I do not overeat… I am on the move all day at work and was walking every day until the weather got terrible. I don’t know what to do. My!!! [the doctor] Also wrote my prescription for my pills wrong last time and if the pharmacist hadn’t caught it and I was following the dosage, I would be dead. He wrote it for 5 pills 3 times a day. That would have killed a horse I’m sure… The office just said, “Oh well… We corrected it.”
“Sheri” (2016, 1 star) said,
Like many others, my doctor prescribed Phentermine wanting me to lose a few pounds. For the first couple of weeks, the only thing I had a problem with was a dry mouth. After about the third week, I started to have anxiety attacks, crying all the time, depression, and heart palpitations. It got so bad I almost ruined my relationship. I told my fiance about it, and he insisted I stop taking the drug and couldn’t believe my doctor would even prescribe something like Phentermine knowing the side effects. In less than 30 days, this drug almost destroyed my entire life. I’m normally a happy and joking person, but the last month has been the most emotionally painful time in my life all because of this little pill. Losing weight on this medication is not worth my sanity.
But “Korey” (2016, 5 stars) had a different experience…or I think so…:
“I started taking prescribed phentermine for weight loss. I weighed 197 lbs. and 6 weeks later I am at 173 and still losing weight. However, I had some issues, depression, and panic attacks that would happen every few mins without medication. I had a thyroid issue and ADD and low libido. I had these things for years starting in my 30’s I am now 52. Phentermine has given me back my life…”
Every supplement affects every individual differently. Gender, age, sometimes race, pre-existing medical conditions, and individual body and brain chemistry—as unique as a fingerprint—can affect how a supplement works on you. That’s why supplements always add that “individual results may vary” disclaimer, and it’s why reviews for a drug or supplement can be all over the spectrum. Only you and your doctor can figure out how it works for you, so always be forthcoming and transparent with your doctor about the side effects you experience, as well as if the substance doesn’t seem to be doing anything for you.
The Bottom Line: Is Acxion Worth Trying?
Risky. Phentermine and its various brands are risky anyway—there’s a reason it’s been banned in over-the-counter forms. It should only be used under the strict supervision of knowledgeable health care professionals for short periods of time, and only after other treatments for severe obesity have failed. And even then you will experience side effects. It’s best to go in with both your own and your doctor’s eyes wide, wide open. Trying to take a shortcut by ordering it from out of the country just risks your health and quite possibly your life. Just don’t, please.